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Article

Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population.

Cancer science - 1 Jun 2007

Jin Guangfu, Miao Ruifen, Deng Yimei, Hu Zhibin, Zhou Yan, Tan Yongfei, Wang Jianming, Hua Zhaolai, Ding Weiliang, Wang Lina, Chen Wensen, Shen Jing, Wang Xinru, Xu Yaochu, Shen Hongbing

Abstract excerpt

Epidermal growth factor (EGF), a ligand of the EGF receptor, plays a critical role in the development of gastric cancer. Genetic variants in its promoter region may influence transcription activity and contribute to gastric cancer predisposition. To test this hypothesis, we genotyped three EGF promoter polymorphisms (G61A, G-1380A, and A-1744G) in a case-control study of 675 gastric cancer cases and 704...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17433039
DOI: 10.1111/j.1349-7006.2007.00463.x
PMCID: PMC11159822

Genes

EGF
AGA
GAA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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