Article
Identification of a quantitative trait locus regulating B cell-dominant infiltration into autoimmune sialitis lesions of the IQI mouse model of primary Sjögren's syndrome.
Immunogenetics - 1 Nov 2007
Konno Akihiro, Takiguchi Mitsuyoshi, Takada Kensuke, Usami Takeshi, Azumi Kaoru, Kubota Hisayo, Inaba Mutsumi, Saegusa Junzo, Kon Yasuhiro
Abstract excerpt
Sjögren's syndrome (SS) is caused by an autoimmune sialodacryoadenitis, and up to 5% of patients with SS develop malignant B cell growth. The IQI mouse is a spontaneous model of primary SS in which B cells are the dominant cellular subpopulation among mononuclear infiltrates in sialitis lesions. Understanding the genetic control of aberrant B cell growth in IQI mice may help elucidate the genetic mechanisms...
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