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Article

Development of an improved preclinical humanized mouse platform representing the diverse clinical phenotypes of Sjögren's syndrome.

Frontiers in immunology - 1 Jan 2026

Park Jin-Sil, Choi JeongWon, Jeong Ha Yeon, Kang Hye Yeon, Cho Sang Hee, Lee Su Beom, Cho Mi-La, Park Sung-Hwan

Abstract excerpt

Background: Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, leading to impaired glandular secretion. To elucidate the pathogenic mechanisms underlying SS, suitable preclinical animal models are essential. In this study, we developed a humanized murine model that captures key immunopathological features of SS patients, and assessed its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42254018
DOI: 10.3389/fimmu.2026.1793493
PMCID: PMC13236660

Genes

CD28
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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