Article
Genetic dissociation of dacryoadenitis and sialadenitis in a Sjogren's syndrome mouse model with common and different susceptibility gene loci.
Investigative ophthalmology & visual science - 1 Jul 2009
Kamao Tomoyuki, Miyazaki Tatsuhiko, Soga Yoshiko, Komori Hiroaki, Terada Miho, Ohashi Yuichi, Nose Masato
Abstract excerpt
PURPOSE: Sjögren's syndrome (SS) is a systemic autoimmune disease in which the main lesions are dacryoadenitis and sialadenitis. It is unclear whether these lesions develop in a common genetic background. A quantitative trait locus (QTL) analysis was performed in the SS mouse model, MRL/MpJ-lpr/lpr (MRL/lpr), to identify the susceptibility loci to dacryoadenitis and sialadenitis and the association with both...
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