Article

Development of the NOD-DR3 as the Spontaneous Humanized Mouse Model for Sjögren’s Disease

2026-07-01

Abstract excerpt

<h4>Background: </h4> Sjögren's disease (SjD) is a chronic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to secretory dysfunction. While conventional mouse models have advanced understanding of disease mechanisms, translational limitations exist due to differences in immune system components, particularly MHC molecules. The NOD-DR3 mouse strain, expressing human HLA-DR3,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3aa966a-f4e9-581a-8442-20a3567ba597
DOI: 10.20944/preprints202607.0051.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of the NOD-DR3 as the Spontaneous Humanized Mouse Model for Sjögren’s DiseaseDOI 10.20944/preprints202607.0051.v1Read

NOD mouse model for Sjögren's syndrome: lack of longitudinal stability.Semantic proximity Read

Sjögren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease.Semantic proximity Read

Contributions of Major Cell Populations to Sjögren’s SyndromeSemantic proximity Read

Development of an improved preclinical humanized mouse platform representing the diverse clinical phenotypes of Sjögren's syndrome.Semantic proximity Read

Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background.Semantic proximity Read

Immune infiltration analysis reveals immune cell signatures in human and mouse model of primary Sjögren's syndrome in salivary gland tissueSemantic proximity Read

Evidence of a Sjögren’s disease-like phenotype following COVID-19Semantic proximity Read

Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren’s-like disease in aging miceSemantic proximity Read

Sjögren's Syndrome‐Like Disease of C57BL/6.NOD‐<i>Aec1 Aec2</i> Mice: Gender Differences in Keratoconjunctivitis Sicca Defined by a Cross‐Over in the Chromosome 3 <i>Aec1</i> LocusSemantic proximity Read

IDD3 and IDD5 alleles from nod mice mediate Sjögren's syndrome-like autoimmunity.Semantic proximity Read

Single-cell transcriptomics reveals a pivotal role of DOCK2 in Sjögren’s diseaseSemantic proximity Read

Assessing the Molecular Validity of Spontaneous Lupus Mouse Models and Its Implication for Human StudiesSemantic proximity Read