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Article

Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease.

Antimicrobial agents and chemotherapy - 1 Jan 2008

Zhou Yi, Bartels Doug J, Hanzelka Brian L, Müh Ute, Wei Yunyi, Chu Hui-May, Tigges Ann M, Brennan Debra L, Rao B Govinda, Swenson Lora, Kwong Ann D, Lin Chao

Abstract excerpt

In patients chronically infected with hepatitis C virus (HCV) strains of genotype 1, rapid and dramatic antiviral activity has been observed with telaprevir (VX-950), a highly selective and potent inhibitor of the HCV NS3-4A serine protease. HCV variants with substitutions in the NS3 protease domain were observed in some patients during telaprevir dosing. In this study, purified protease domain proteins and...

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Identifiers

PMID: 17938182
DOI: 10.1128/AAC.00863-07
PMCID: PMC2223918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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