Article
Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations.
The Journal of biological chemistry - 24 Mar 2006
Yi MinKyung, Tong Xiao, Skelton Angela, Chase Robert, Chen Tong, Prongay Andrew, Bogen Stephane L, Saksena Anil K, Njoroge F George, Veselenak Ronald L, Pyles Richard B, Bourne Nigel, Malcolm Bruce A, Lemon Stanley M
Abstract excerpt
Drug resistance is a major issue in the development and use of specific antiviral therapies. Here we report the isolation and characterization of hepatitis C virus RNA replicons resistant to a novel ketoamide inhibitor of the NS3/4A protease, SCH6 (originally SCH446211). Resistant replicon RNAs were generated by G418 selection in the presence of SCH6 in a dose-dependent fashion, with the emergence of resistance...
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