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Article

Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.

The Journal of biological chemistry - 3 Aug 2007

Zhou Yi, Müh Ute, Hanzelka Brian L, Bartels Doug J, Wei Yunyi, Rao B Govinda, Brennan Debra L, Tigges Ann M, Swenson Lora, Kwong Ann D, Lin Chao

Abstract excerpt

Telaprevir (VX-950) is a highly selective, potent inhibitor of the hepatitis C virus (HCV) NS3.4A serine protease. It has demonstrated strong antiviral activity in patients chronically infected with genotype 1 HCV when dosed alone or in combination with peginterferon alfa-2a. Substitutions of Arg(155) of the HCV NS3 protease domain have been previously detected in HCV isolates from some patients during telaprevir...

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Identifiers

PMID: 17556358
DOI: 10.1074/jbc.M610207200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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