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Article

Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3.

Antiviral therapy - 1 Jan 2007

Dahl Göran, Sandström Anja, Akerblom Eva, Danielson U Helena

Abstract excerpt

BACKGROUND: The NS3 protease of hepatitis C virus (HCV) is a prime target for anti-HCV drugs but resistance towards inhibitors of the enzyme is likely to emerge because of mutations in the viral genome that modify the structure of the protein. Enzyme inhibition data supporting this is limited to studies with few compounds and analysis performed with truncated NS3. EXPERIMENTAL: The potential of HCV acquiring...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17713156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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