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Article

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

26 Jul 2012

Abstract excerpt

Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral therapies cause severe side effects and are effective only for a subset of patients, though treatment outcomes have recently been improved by the combination therapy now including boceprevir and telaprevir, which inhibit the...

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PMID: 22910833
DOI: 10.1371/journal.ppat.1002832

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