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Article

Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir.

Gastroenterology - 1 May 2007

Sarrazin Christoph, Kieffer Tara L, Bartels Doug, Hanzelka Brian, Müh Ute, Welker Martin, Wincheringer Dennis, Zhou Yi, Chu Hui-May, Lin Chao, Weegink Christine, Reesink Henk, Zeuzem Stefan, Kwong Ann D

Abstract excerpt

BACKGROUND & AIMS: Telaprevir (VX-950), a hepatitis C virus (HCV) NS3.4A protease inhibitor, has shown strong antiviral activity in phase 1 clinical studies. Because of high levels of HCV replication and the low fidelity of HCV polymerase, selection of resistant isolates during therapy may occur. METHODS: A highly sensitive sequencing method was developed in which approximately 80 clones/sample were analyzed to...

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PMID: 17484874
DOI: 10.1053/j.gastro.2007.02.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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