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Article

Hepatitis C virus resistance to protease inhibitors.

Journal of hepatology - 1 Jul 2011

Halfon Philippe, Locarnini Stephen

Abstract excerpt

Recent advances in molecular biology have led to the development of novel small molecules that target specific viral proteins of the hepatitis C virus (HCV) life cycle. These drugs, collectively termed directly acting antivirals (DAA) against HCV, include a range of non-structural (NS) 3/NS4A protease, NS5B polymerase, and NS5A inhibitors at various stages of clinical development. The rapid replication rate of...

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Identifiers

PMID: 21284949
DOI: 10.1016/j.jhep.2011.01.011

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