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Article

Exploring the differences between mouse mAβ(1-42) and human hAβ(1-42) for Alzheimer's disease related properties and neuronal cytotoxicity.

Chemical communications (Cambridge, England) - 4 Jul 2013

Lv Xiaoping, Li Wei, Luo Ying, Wang Dandan, Zhu Cuiqing, Huang Zhong-Xian, Tan Xiangshi

Abstract excerpt

The differences between mouse mAβ(1-42) and human hAβ(1-42), explored using CD and fluorescence spectroscopy, transmission electron microscopy, ROS fluorescent assay, and neuronal cell viability, revealed that mAβ(1-42) as a three-site mutant (R5G, Y10F and H13R) of hAβ(1-42) altered the metal (copper and zinc) binding sites, reduced the proneness to form β-sheet structures and aggregated fibrils, alleviated the...

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PMID: 23700581
DOI: 10.1039/c3cc40779a

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