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Article

Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease.

The European journal of neuroscience - 1 Apr 2009

Rival Thomas, Page Richard M, Chandraratna Dhianjali S, Sendall Timothy J, Ryder Edward, Liu Beinan, Lewis Huw, Rosahl Thomas, Hider Robert, Camargo L M, Shearman Mark S, Crowther Damian C, Lomas David A

Abstract excerpt

The mechanism by which aggregates of the beta-amyloid peptide (Abeta) mediate their toxicity is uncertain. We show here that the expression of the 42-amino-acid isoform of Abeta (Abeta(1-42)) changes the expression of genes involved in oxidative stress in a Drosophila model of Alzheimer's disease. A subsequent genetic screen confirmed the importance of oxidative stress and a molecular dissection of the steps in...

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Identifiers

PMID: 19519625
DOI: 10.1111/j.1460-9568.2009.06701.x
PMCID: PMC2777252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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