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Natural Non-Trasgenic Animal Models for Research in Alzheimers Disease

6 Mar 2009

Abstract excerpt

The most common animal models currently used for Alzheimer disease (AD) research are transgenic mice that express a mutant form of human Abeta precursor protein (APP) and/or some of the enzymes implicated in their metabolic processing. However, these transgenic mice carry their own APP and APP-processing enzymes, which may interfere in the production of different amyloid-beta (Abeta) peptides encoded by the human...

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PMID: 19355852
DOI: 10.2174/156720509787602834

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