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Article

Tripeptidyl peptidase II promotes fat formation in a conserved fashion.

EMBO reports - 1 Dec 2007

McKay Renée M, McKay James P, Suh Jae Myoung, Avery Leon, Graff Jonathan M

Abstract excerpt

Tripeptidyl peptidase II (TPPII) is a multifunctional and evolutionarily conserved protease. In the mammalian hypothalamus, TPPII has a proposed anti-satiety role affected by degradation of the satiety hormone cholecystokinin 8. Here, we show that TPPII also regulates the metabolic homoeostasis of Caenorhabditis elegans; TPPII RNA interference (RNAi) decreases worm fat stores. However, this occurs independently...

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Source

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Identifiers

PMID: 17932511
DOI: 10.1038/sj.embor.7401086
PMCID: PMC2267238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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