Article
A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism.
Nature communications - 27 Jan 2017
Palamiuc Lavinia, Noble Tallie, Witham Emily, Ratanpal Harkaranveer, Vaughan Megan, Srinivasan Supriya
Abstract excerpt
Serotonin, a central neuromodulator with ancient ties to feeding and metabolism, is a major driver of body fat loss. However, mechanisms by which central serotonin action leads to fat loss remain unknown. Here, we report that the FLP-7 neuropeptide and its cognate receptor, NPR-22, function as the ligand-receptor pair that defines the neuroendocrine axis of serotonergic body fat loss in Caenorhabditis elegans....
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