Article

MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity

2019-10-13

Abstract excerpt

The ciliopathies Bardet-Biedl Syndrome and Alström Syndrome are genetically inherited pleiotropic disorders with primary clinical features of hyperphagia and obesity. Methionine aminopeptidase 2 inhibitors (MetAP2i) have been shown in preclinical and clinical studies to reduce food intake, body weight, and adiposity. Here we investigated the effects of MetAP2i administration in a mouse model of ciliopathy produced...

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Literature Corpus work: 98bcaa7a-69fc-5f4c-b384-a1b3bc27f18c
DOI: 10.1101/800151

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