Article
Assignment of two loci for autosomal dominant adolescent idiopathic scoliosis to chromosomes 9q31.2-q34.2 and 17q25.3-qtel.
Journal of medical genetics - 1 Feb 2008
Ocaka L, Zhao C, Reed J A, Ebenezer N D, Brice G, Morley T, Mehta M, O'Dowd J, Weber J L, Hardcastle A J, Child A H
Abstract excerpt
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, affecting up to 4% of children worldwide. Familial inheritance of AIS is now recognised and several potential candidate loci have been found. METHODS: We studied 25 multi-generation AIS families of British descent with at least 3 affected members in each family. A genomewide screen was performed using microsatellite...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.