Article
Genetic linkage localizes an adolescent idiopathic scoliosis and pectus excavatum gene to chromosome 18 q.
Spine - 15 Jan 2009
Gurnett Christina A, Alaee Farhang, Bowcock Anne, Kruse Lisa, Lenke Lawrence G, Bridwell Keith H, Kuklo Timothy, Luhmann Scott J, Dobbs Matthew B
Abstract excerpt
STUDY DESIGN: A single large family, in which adolescent idiopathic scoliosis (AIS) and pectus excavatum (PE) segregate as an autosomal dominant condition, was evaluated. Genome-wide linkage analysis and candidate gene sequencing were performed. OBJECTIVE: To map the disease-causing locus in a large white family in which AIS and PE cosegregate. SUMMARY OF BACKGROUND DATA: AIS and PE are common musculoskeletal...
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