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Article

Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans.

Journal of hepatology - 1 Jan 2008

Kovacs Peter, Kress Rahel, Rocha Jacqueline, Kurtz Ulrike, Miquel Juan Francisco, Nervi Flavio, Méndez-Sánchez Nahum, Uribe Misael, Bock Hans H, Schirin-Sokhan Ramin, Stumvoll Michael, Mössner Joachim, Lammert Frank, Wittenburg Henning

Abstract excerpt

BACKGROUND/AIMS: From quantitative trait locus mapping in inbred mice, we identified the Nr1h4 gene encoding the nuclear bile salt receptor FXR as a candidate gene for the cholesterol gallstone susceptibility locus Lith7. Here, we investigated further an association of the gene encoding FXR and gallstone susceptibility in mice and humans. METHODS: The Nr1h4 gene was sequenced in inbred mouse strains with...

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Identifiers

PMID: 17931734
DOI: 10.1016/j.jhep.2007.07.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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