Article
Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of mice.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1995
Khanuja B, Cheah Y C, Hunt M, Nishina P M, Wang D Q, Chen H W, Billheimer J T, Carey M C, Paigen B
Abstract excerpt
The prevalence of cholesterol gallstones differs among inbred strains of mice fed a diet containing 15% (wt/wt) dairy fat, 1% (wt/wt) cholesterol, and 0.5% (wt/wt) cholic acid. Strains C57L, SWR, and A were notable for a high prevalence of cholelithiasis; strains C57BL/6, C3H, and SJL had an intermediate prevalence; and strains SM, AKR, and DBA/2 exhibited no cholelithiasis after consuming the diet for 18 weeks....
Topics
- Animals
- Aorta
- Cholelithiasis
- Cholesterol
- Cholesterol, HDL
- Crosses, Genetic
- Gallbladder
- Genetic Predisposition to Disease
- Lipoproteins
- Mice
- Mice, Inbred A