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Article

Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2005

Lyons Malcolm A, Korstanje Ron, Li Renhua, Sheehan Susan M, Walsh Kenneth A, Rollins Jarod A, Carey Martin C, Paigen Beverly, Churchill Gary A

Abstract excerpt

Quantitative trait locus (QTL) mapping was employed to investigate the genetic determinants of cholesterol gallstone formation in a large intercross between mouse strains SM/J (resistant) and NZB/B1NJ (susceptible). Animals consumed a gallstone-promoting diet for 18 weeks. QTL analyses were performed using gallstone weight and gallstone absence/presence as phenotypes; various models were explored for genome...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 15834632
DOI: 10.1007/s00335-004-2446-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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