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Article

New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice.

Physiological genomics - 15 Aug 2003

Lyons Malcolm A, Wittenburg Henning, Li Renhua, Walsh Kenneth A, Leonard Monika R, Churchill Gary A, Carey Martin C, Paigen Beverly

Abstract excerpt

Cholesterol gallstone formation is a response to interactions between multiple genes and environmental stimuli. To determine the subset of cholesterol gallstone susceptibility (Lith) genes possessed by strains CAST/Ei (susceptible) and 129S1/SvImJ (resistant), we conducted quantitative trait locus (QTL) analyses of an intercross between these strains. Parental strains and F(1) mice of both genders were evaluated...

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PMID: 12837957
DOI: 10.1152/physiolgenomics.00073.2003

Genes

CAST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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