Article
The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses.
Biomaterials - 1 Oct 2009
Kayamuro Hiroyuki, Abe Yasuhiro, Yoshioka Yasuo, Katayama Kazufumi, Nomura Tetsuya, Yoshida Tokuyuki, Yamashita Kohei, Yoshikawa Tomoaki, Kawai Yuichi, Mayumi Tadanori, Hiroi Takachika, Itoh Norio, Nagano Kazuya, Kamada Haruhiko, Tsunoda Shin-ichi, Tsutsumi Yasuo
Abstract excerpt
Safe and potent adjuvants are required in order to establish effective mucosal vaccines. Cytokines are promising adjuvants because they are human-derived safe biomaterial and display immune-modulating functions. We have created a mutant tumor necrosis factor-alpha (TNF-alpha), mTNF-K90R, that exhibits high bioactivity and resistance to proteases. Here, we examined the potential of mTNF-K90R as a mucosal adjuvant....
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