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Bile reflux and hypopharyngeal cancer (Review)

23 Sept 2021

Abstract excerpt

Laryngopharyngeal reflux, a variant of gastroesophageal reflux disease, has been considered a risk factor in the development of hypopharyngeal cancer. Bile acids are frequently present in the gastroesophageal refluxate and their effect has been associated with inflammatory and neoplastic changes in the upper aerodigestive tract. Recent in vitro and in vivo studies have provided direct evidence of the role of...

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PMID: 34558652
DOI: 10.3892/or.2021.8195

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