Article
In vivo detection of mutations induced by aflatoxin B1 using human CYP3A7/HITEC hybrid mice.
Biochemical and biophysical research communications - 8 Sept 1998
Yamada A, Fujita K, Yokoi T, Muto S, Suzuki A, Gondo Y, Katsuki M, Kamataki T
Abstract excerpt
CYP3A7-M10 mouse is a transgenic mouse carrying human CYP3A7 cDNA, in which CYP3A7 is expressed in the small intestine but not in the kidney. HITEC mouse is a transgenic mouse developed to detect mutagenic potency of various chemicals in vivo. The M10/HITEC mouse was established by crossmating of...
Topics
- Aflatoxin B1
- Animals
- Aryl Hydrocarbon Hydroxylases
- Catalysis
- Crosses, Genetic
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Humans
- Intestine, Small
- Kidney
- Male
- Mice
- Mutation
- Transgenes