Article
In vivo detection of mutations induced by aflatoxin B1 using human CYP3A7/HITEC hybrid mice.
Biochemical and biophysical research communications - 8 Sept 1998
Yamada A, Fujita K, Yokoi T, Muto S, Suzuki A, Gondo Y, Katsuki M, Kamataki T
Abstract excerpt
CYP3A7-M10 mouse is a transgenic mouse carrying human CYP3A7 cDNA, in which CYP3A7 is expressed in the small intestine but not in the kidney. HITEC mouse is a transgenic mouse developed to detect mutagenic potency of various chemicals in vivo. The M10/HITEC mouse was established by crossmating of these two strains of mice. When a 9,000 x g supernatant fraction prepared from the small intestine was added to an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.