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Article

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.

Nature genetics - 1 Oct 2000

Liu W, Dong X, Mai M, Seelan R S, Taniguchi K, Krishnadath K K, Halling K C, Cunningham J M, Boardman L A, Qian C, Christensen E, Schmidt S S, Roche P C, Smith D I, Thibodeau S N

Abstract excerpt

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Topics

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Share to Axin Protein
Share to Base Pair Mismatch
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Genes, Reporter

Share to TCF Transcription Factors

Share to Trans-Activators

Share to Transcription Factor 7-Like 2 Protein

Source

Identifiers

PMID: 11017067
DOI: 10.1038/79859

Genes

AXIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.PMID 11017067Read ↗

AXIN1 and AXIN2 variants in gastrointestinal cancers.Semantic proximity Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer.Semantic proximity Read ↗

Mismatch repair deficiency concordance between primary colorectal cancer and corresponding metastasisSemantic proximity Read ↗

Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanomaSemantic proximity Read ↗

DDB2 Is a Novel Regulator of Wnt Signaling in Colon CancerSemantic proximity Read ↗

Axin1 Protects Colon Carcinogenesis by an Immune-Mediated EffectSemantic proximity Read ↗

Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding.Semantic proximity Read ↗

Variations in AXIN2 predict risk and prognosis of colorectal cancerSemantic proximity Read ↗

Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin SignalingSemantic proximity Read ↗

Rare germline variants in the AXIN2 gene in families with colonic polyposis and colorectal cancer.Semantic proximity Read ↗

Diversity of axin in signaling pathways and its relation to colorectal cancer.Semantic proximity Read ↗

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