Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function.

Neoplasia (New York, N.Y.) - 1 May 2015

Mazzoni Serina M, Petty Elizabeth M, Stoffel Elena M, Fearon Eric R

Abstract excerpt

Heterozygous, germline nonsense mutations in AXIN2 have been reported in two families with oligodontia and colorectal cancer (CRC) predisposition, including an AXIN2 1989G>A mutation. Somatic AXIN2 mutations predicted to generate truncated AXIN2 (trAXIN2) proteins have been reported in some CRCs. Our studies of cells from an AXIN2 1989G>A mutation carrier showed that the mutant transcripts are not significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axin Protein
Share to Codon, Nonsense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Germ-Line Mutation

Share to Immunoblotting

Share to Immunoprecipitation

Share to Mutagenesis, Site-Directed

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 26025668
DOI: 10.1016/j.neo.2015.04.006
PMCID: PMC4468370

Genes

AXIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function.PMID 26025668Read ↗

Rare germline variants in the AXIN2 gene in families with colonic polyposis and colorectal cancer.Semantic proximity Read ↗

AXIN2 germline testing in a French cohort validates pathogenic variants as a rare cause of predisposition to colorectal polyposis and cancer.Semantic proximity Read ↗

AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome.Semantic proximity Read ↗

Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin SignalingSemantic proximity Read ↗

Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding.Semantic proximity Read ↗

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.Semantic proximity Read ↗

AXIN1 and AXIN2 variants in gastrointestinal cancers.Semantic proximity Read ↗

Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.Semantic proximity Read ↗

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.Semantic proximity Read ↗

Mouse axin and axin2/conductin proteins are functionally equivalent in vivo.Semantic proximity Read ↗

The links between axin and carcinogenesisSemantic proximity Read ↗

Case report expanding the germline AXIN2- related phenotype to include olfactory neuroblastoma and gastric adenoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.