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Article

The evolutionary history of TLR4 polymorphisms in Europe.

Journal of innate immunity - 1 Jan 2012

Plantinga Theo S, Ioana Mihai, Alonso Santos, Izagirre Neskuts, Hervella Montserrat, Joosten Leo A B, van der Meer Jos W M, de la Rúa Concepcion, Netea Mihai G

Abstract excerpt

Infections exert important evolutionary pressures shaping the human genome, especially on genes involved in host defense. A crucial step for host defense is recognition of pathogens by pattern recognition receptors on innate immune cells, among which Toll-like receptor 4 (TLR4) is one of the best known. Genetic variation in TLR4 (Asp299Gly, Thr399Ile) has been recently described. Haplotype frequencies of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21968286
DOI: 10.1159/000329492
PMCID: PMC6741577

Genes

TLR4

Provenance

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