Article
In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized.
Infection and immunity - 1 Dec 2007
Miura Kazutoyo, Zhou Hong, Muratova Olga V, Orcutt Andrew C, Giersing Birgitte, Miller Louis H, Long Carole A
Abstract excerpt
At least a million people, mainly African children under 5 years old, still die yearly from malaria, and the burden of disease and death has increased. Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is one of the most promising blood-stage malarial vaccine candidates. However, the allelic polymorphism observed in this protein is a potential stumbling block for vaccine development. To overcome the...
Topics
- Alleles
- Animals
- Antibodies, Protozoan
- Antibody Formation
- Antibody Specificity
- Antigens, Protozoan
- Enzyme-Linked Immunosorbent Assay
- Macaca mulatta
- Malaria Vaccines
- Malaria, Falciparum
- Membrane Proteins
- Mice
- Mice, Inbred BALB C