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Article

Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity.

PloS one - 1 Dec 2009

Kusi Kwadwo A, Faber Bart W, Thomas Alan W, Remarque Edmond J

Abstract excerpt

Apical Membrane Antigen 1 (AMA1), a merozoite protein essential for red cell invasion, is a candidate malaria vaccine component. Immune responses to AMA1 can protect in experimental animal models and antibodies isolated from AMA1-vaccinated or malaria-exposed humans can inhibit parasite multiplication in vitro. The parasite is haploid in the vertebrate host and the genome contains a single copy of AMA1, yet on a...

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Source

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Identifiers

PMID: 19956619
DOI: 10.1371/journal.pone.0008110
PMCID: PMC2779588

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity.PMID 19956619Read ↗

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Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.Semantic proximity Read ↗

A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits.Semantic proximity Read ↗

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