Article
Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1.
PloS one - 1 Jan 2011
Biswas Sumi, Dicks Matthew D J, Long Carole A, Remarque Edmond J, Siani Loredana, Colloca Stefano, Cottingham Matthew G, Holder Anthony A, Gilbert Sarah C, Hill Adrian V S, Draper Simon J
Abstract excerpt
BACKGROUND: Apical membrane antigen 1 (AMA1) is a leading candidate vaccine antigen against blood-stage malaria, although to date numerous clinical trials using mainly protein-in-adjuvant vaccines have shown limited success. Here we describe the pre-clinical development and optimization of recombinant human and simian adenoviral (AdHu5 and ChAd63) and orthopoxviral (MVA) vectors encoding transgene inserts for...
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