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Article

Specificity of the Protective Antibody Response to Apical Membrane Antigen 1

1 May 2001

Abstract excerpt

Apical membrane antigen 1 (AMA1) is considered one of the leading candidates for inclusion in a vaccine against blood stages of Plasmodium falciparum. Although the ama1 gene is relatively conserved compared to those for some other potential vaccine components, numerous point mutations have resulted in amino acid substitutions at many sites in the polypeptide. The polymorphisms in AMA1 have been attributed to the...

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PMID: 11292751
DOI: 10.1128/iai.69.5.3286-3294.2001

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Specificity of the Protective Antibody Response to Apical Membrane Antigen 1PMID 11292751Read ↗

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Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria.Semantic proximity Read ↗

In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized.Semantic proximity Read ↗

The Most Polymorphic Residue on Plasmodium falciparum Apical Membrane Antigen 1 Determines Binding of an Invasion-Inhibitory AntibodySemantic proximity Read ↗

In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic response.Semantic proximity Read ↗

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