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Article

Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.

Infection and immunity - 1 May 2013

Miura Kazutoyo, Herrera Raul, Diouf Ababacar, Zhou Hong, Mu Jianbing, Hu Zonghui, MacDonald Nicholas J, Reiter Karine, Nguyen Vu, Shimp Richard L, Singh Kavita, Narum David L, Long Carole A, Miller Louis H

Abstract excerpt

Apical membrane antigen 1 (AMA1) is a leading vaccine candidate, but the allelic polymorphism is a stumbling block for vaccine development. We previously showed that a global set of AMA1 haplotypes could be grouped into six genetic populations. Using this information, six recombinant AMA1 proteins representing each population were produced. Rabbits were immunized with either a single recombinant AMA1 protein or...

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Identifiers

PMID: 23429537
DOI: 10.1128/IAI.01414-12
PMCID: PMC3648006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.PMID 23429537Read ↗

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A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbits.Semantic proximity Read ↗

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