Article
The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila.
Cell - 5 Oct 2007
Karres Janina S, Hilgers Valérie, Carrera Ines, Treisman Jessica, Cohen Stephen M
Abstract excerpt
microRNAs (miRNAs) bind to specific messenger RNA targets to posttranscriptionally modulate their expression. Understanding the regulatory relationships between miRNAs and targets remains a major challenge. Many miRNAs reduce expression of their targets to inconsequential levels. It has also been proposed that miRNAs might adjust target expression to an optimal level. Here we analyze the consequences of mutating...
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