Article
Drosophila atrophin homolog functions as a transcriptional corepressor in multiple developmental processes.
Cell - 11 Jan 2002
Zhang Sheng, Xu Lei, Lee Janet, Xu Tian
Abstract excerpt
Dentatorubral-pallidoluysian atrophy is a progressive neurodegenerative disease caused by the expansion of a polyglutamine repeats within the Atrophin-1 protein. The in vivo function of Atrophin-1 is unknown. We have characterized a Drosophila gene encoding an Atrophin family protein. Analysis of mutant phenotypes indicates that Drosophila Atrophin is required in diverse developmental processes including early...
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