Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology.

The Journal of biological chemistry - 22 Nov 2002

Dunty Jill M, Schaller Michael D

Abstract excerpt

The focal adhesion kinase (FAK) and cell adhesion kinase beta (CAKbeta, PYK2, CADTK, RAFTK) are highly homologous FAK family members, yet clearly have unique roles in the cell. Comparative analyses of FAK and CAKbeta have revealed intriguing differences in their activities. These differences were investigated further through the characterization of a set of FAK/CAKbeta chimeric kinases. CAKbeta exhibited greater...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Size
Share to Chick Embryo
Share to CSK Tyrosine-Protein Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Kinase 2

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Protein-Tyrosine Kinases

Share to src-Family Kinases

Share to Tyrosine

Source

Identifiers

PMID: 12223467
DOI: 10.1074/jbc.M201779200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology.PMID 12223467Read ↗

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development and TherapySemantic proximity Read ↗

FAK regulates biological processes important for the pathogenesis of cancer.Semantic proximity Read ↗

Interactions between two cytoskeleton-associated tyrosine kinases: calcium-dependent tyrosine kinase and focal adhesion tyrosine kinase.Semantic proximity Read ↗

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer DevelopmentSemantic proximity Read ↗

Understanding the Roles of FAK in CancerSemantic proximity Read ↗

A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly.Semantic proximity Read ↗

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.Semantic proximity Read ↗

Focal adhesion kinase (FAK): emerging target for drug-resistant malignant tumorsSemantic proximity Read ↗

Control of motile and invasive cell phenotypes by focal adhesion kinase.Semantic proximity Read ↗

New Insights on the Nuclear Functions and Targeting of FAK in CancerSemantic proximity Read ↗

Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation.Semantic proximity Read ↗

Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.