Article
Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation.
Biochimica et biophysica acta - 21 Oct 2002
Katz Ben-Zion, Miyamoto Shingo, Teramoto Hidemi, Zohar Muriel, Krylov Dmitry, Vinson Charles, Gutkind J Silvio, Yamada Kenneth M
Abstract excerpt
We investigated mechanisms for inducing focal adhesion kinase (FAK) tyrosine phosphorylation and their ability to trigger MAP kinase signaling using transmembrane chimeras that localize FAK and its mutants to the plasma membrane. We tested whether tyrosine phosphorylation was triggered by FAK transmembrane aggregation using antibodies against the chimeric extracellular domain. Experimental clustering of chimeras...
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