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The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer.

Breast cancer research and treatment - 1 Sept 2008

Justenhoven Christina, Pierl Christiane B, Haas Susanne, Fischer Hans-Peter, Baisch Christian, Hamann Ute, Harth Volker, Pesch Beate, Brüning Thomas, Vollmert Caren, Illig Thomas, Dippon Jürgen, Ko Yon-Dschun, Brauch Hiltrud

Abstract excerpt

Cytochrome P450 1B1 (CYP1B1) is a major enzyme in the initial catabolic step of estradiol (E2) metabolism and belongs to the multitude of genes regulated by the estrogen receptor alpha (ERalpha). The common non-synonymous polymorphisms CYP1B1_1358_A>G and CYP1B1_1294_C>G increase CYP1B1 enzymatic activity. Given a relationship between CYP1B1 and breast tumor E2 level as well as E2 level and breast tumor ERalpha...

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PMID: 17922187
DOI: 10.1007/s10549-007-9762-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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