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Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk

23 Jul 2019

Abstract excerpt

Breast cancer in men is a rare and still poorly characterized disease. Inherited mutations in BRCA1, BRCA2 and PALB2 genes, as well as common polymorphisms, play a role in male breast cancer genetic predisposition. Male breast cancer is considered a hormone-dependent tumor specifically related to hyperestrogenism. Polymorphisms in genes involved in estrogen biosynthesis and metabolism pathways, such as CYP17A1...

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PMID: 31336362
DOI: 10.1530/ec-19-0225

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