Article
In vitro expansion affects the response of chondrocytes to mechanical stimulation.
Osteoarthritis and cartilage - 1 Mar 2008
Das R H J, Jahr H, Verhaar J A N, van der Linden J C, van Osch G J V M, Weinans H
Abstract excerpt
OBJECTIVE: Expansion of autologous chondrocytes is a common step in procedures for cartilage defect repair. Subsequent dedifferentiation can alter cellular response to mechanical loading, having major consequences for the cell's behavior in vivo after reimplantation. Therefore, we examined the response of primary and expanded human articular chondrocytes to mechanical loading. METHOD: Primary and expanded...
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