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Article

Control of human articular chondrocyte differentiation by reduced oxygen tension.

Journal of cellular physiology - 1 Jun 2004

Murphy Christopher L, Polak Julia M

Abstract excerpt

Cell number is often a limiting factor in studies of chondrocyte physiology, particularly for human investigations. Chondrocytes can be readily proliferated in monolayer culture, however, differentiated phenotype is soon lost. We therefore endeavored to restore normal phenotype to human chondrocytes after serial passage in monolayer culture by manipulating cell morphology and oxygen tension towards the in vivo...

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PMID: 15095292
DOI: 10.1002/jcp.10481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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