Article
Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture.
Matrix biology : journal of the International Society for Matrix Biology - 1 Jul 2004
Mandl E W, Jahr H, Koevoet J L M, van Leeuwen J P T M, Weinans H, Verhaar J A N, van Osch G J V M
Abstract excerpt
The loss of the differentiated phenotype (dedifferentiation) during the expansion culture of donor chondrocytes remains a large problem in cartilage tissue engineering. Dedifferentiated chondrocytes produce other matrix components and therefore the tissue produced will be of less suitable quality. Previously, the addition of fibroblast growth factor-2 (FGF2) to a serum-containing medium (SCM) during expansion...
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