Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of the C.886C>T Mutation in the Mouse Tyrosine Hydroxylase Gene on Behavior and Dopamine System of the Brain.

Biochemistry. Biokhimiia - 1 Jul 2026

Alsalloum Ismail, Rakhov Ilya A, Komleva Polina D, Kuranova Valentina N, Bastrikova Anastasia E, Kulikov Alexander V, Bazovkina Darya V

Abstract excerpt

Dopamine (DA) is a critical regulator of physiological functions and adaptive behavior. The enzyme tyrosine hydroxylase (TH) catalyzes hydroxylation of L-tyrosine to 3,4-dihydroxyphenylalanine (DOPA), which is the first and rate-limiting step in the DA biosynthesis. Mutations in the human TH gene have been linked to dystonia, catalepsy, and catatonia. In the present study, we examined how the functional mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dopamine

Share to Genotype

Share to Mice, Inbred C57BL

Share to Mutation

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 42633718
DOI: 10.1134/S0006297926600171

Genes

TH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of the C.886C>T Mutation in the Mouse Tyrosine Hydroxylase Gene on Behavior and Dopamine System of the Brain.PMID 42633718Read ↗

The C886T Mutation in the Th Gene Reduces the Activity of Tyrosine Hydroxylase in the Mouse Brain.Semantic proximity Read ↗

Tyrosine Hydroxylase Deficiency Impairs TH Axonal Transport, Brain Function, and Neuronal Plasticity.Semantic proximity Read ↗

Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes.Semantic proximity Read ↗

Active tyrosine hydroxylase mutant in genome-edited mice leads to lower enzyme levels in the striatum.Semantic proximity Read ↗

Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.Semantic proximity Read ↗

C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test.Semantic proximity Read ↗

Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and psychiatric diseaseSemantic proximity Read ↗

Effects of the Combination of the C1473G Mutation in the Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior, Brain 5-HT and Melanocortin Systems in Mice.Semantic proximity Read ↗

Analysis of the mesotelencephalic dopamine system by quantitative-trait locus introgression.Semantic proximity Read ↗

Distribution of the C1473G polymorphism in tryptophan hydroxylase 2 gene in laboratory and wild mice.Semantic proximity Read ↗

Effect of genetic modifications in the synaptic dopamine clearance systems on addiction-like behaviour in mice.Semantic proximity Read ↗

Characterization of a novel mouse model of Dopamine Transporter Deficiency Syndrome and pharmacological therapeutic strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.