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Article

Normal nigrostriatal innervation but dopamine dysfunction in mice carrying hypomorphic tyrosine hydroxylase alleles.

Journal of neuroscience research - 15 May 2003

Althini Susanna, Bengtsson Henrik, Usoskin Dmitry, Söderström Stine, Kylberg Annika, Lindqvist Eva, Chuva de Sousa Lopes Susana, Olson Lars, Lindeberg Jonas, Ebendal Ted

Abstract excerpt

We investigated the use of the mouse tyrosine hydroxylase (TH) gene to drive knock-in constructs in catecholaminergic neurons. Two targeting constructs representing truncated forms of either of the BMP receptors ALK-2 or BMPR-II preceded by an internal ribosome entry site (IRES) were introduced into the 3' untranslated region of TH. An frt-flanked neomycin-resistance (neo(r)) cassette was placed in the 3' end of...

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Identifiers

PMID: 12704806
DOI: 10.1002/jnr.10606

Genes

ALK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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