Article
MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences.
Behavior genetics - 1 May 2000
Sedelis M, Hofele K, Auburger G W, Morgan S, Huston J P, Schwarting R K
Abstract excerpt
To investigate the impact of strain and sex in the l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of Parkinson's disease, C57BL/6 and BALB/c mice were treated with either systemic MPTP-HCl (4 x 15 mg/kg) or saline and were examined in a number of behavioral tests. Furthermore, neostriatal and ventral striatal monoamine contents were determined, and the numbers of tyrosine...
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