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Article

A growth and division model for retinoblastoma.

Mathematical biosciences - 1 Feb 2008

Shonkwiler R, Mistretta M, Varma V

Abstract excerpt

A stochastic growth and division model for studying a two hit cancer is developed and applied to retinoblastoma. Retinoblastoma occurs if both genes coding for a tumor suppressor protein on homologous chromosomes become defective. Germinal cases occur when a patient or carrier, born with one defective gene, suffers a second insult to any progeny retinal cell. Somatic cases are far less likely as two hits to the...

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PMID: 17920081
DOI: 10.1016/j.mbs.2007.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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