Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-specific incidence of inherited versus sporadic cancers: a test of the multistage theory of carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2005

Frank Steven A

Abstract excerpt

Knudson [Knudson, A. G. (1971) Proc. Natl. Acad. Sci. USA 68, 820-823] suggested that progression of retinoblastoma follows from two mutational events. Individuals who inherit one mutated gene copy should follow an age-onset pattern set by only a single rate-limiting step for transformation, whereas normal individuals should follow an age-onset pattern set by two rate-limiting events. Knudson's analysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Aged
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Eye Neoplasms

Share to Genetic Predisposition to Disease

Share to Incidence

Share to Neoplasms

Share to Retinoblastoma

Source

Open in PubMed Open full text

Identifiers

PMID: 15657129
DOI: 10.1073/pnas.0407299102
PMCID: PMC545832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-specific incidence of inherited versus sporadic cancers: a test of the multistage theory of carcinogenesis.PMID 15657129Read ↗

A population perspective on multistage carcinogenesis.Semantic proximity Read ↗

The population genetics of multistage carcinogenesis.Semantic proximity Read ↗

Age-specific incidence of cancer: Phases, transitions, and biological implicationsSemantic proximity Read ↗

Estimating the carcinogenesis timelines in early-onset versus late-onset cancers and changes across birth cohortsSemantic proximity Read ↗

Estimating the carcinogenesis timelines in early-onset versus late-onset cancers and changes across birth cohorts.Semantic proximity Read ↗

The two-hit theory hits 50.Semantic proximity Read ↗

The two-stage mutation model in retinal hemangioblastoma.Semantic proximity Read ↗

Multistage carcinogenesis and the incidence of colorectal cancerSemantic proximity Read ↗

Dominant inheritance in human cancer.Semantic proximity Read ↗

A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates.Semantic proximity Read ↗

Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States.Semantic proximity Read ↗

Genetic hits and mutation rate in colorectal tumorigenesis: versatility of Knudson's theory and implications for cancer prevention.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.