Article
Retinoblastoma: a model for deriving the mutation rate without using any estimate of the size of the population at risk.
Mutation research - 1 Jan 1995
Lloyd R A, Papworth D G
Abstract excerpt
Paediatric cancer of the retinae arises from a transient population of stem cells whose growth and decay are responsible for the development of the fully differentiated photo-receptors and nerve cells. A model is described which fits the data on the incidence of bilateral retinoblastoma and gives the somatic mutation rate without using an estimate of the size of the population at risk. It also gives the shape of...
Topics
- Age Factors
- Child
- Child, Preschool
- Eye Neoplasms
- Humans
- Incidence
- Infant
- Infant, Newborn
- Models, Genetic
- Models, Statistical
- Mutation
- Retinoblastoma